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27.   Lin Y, Yu B, Fang P, Wang J. Inhibiting autophagy before it starts. Autophagy. doi: 10.1080/15548627.2023.2197364. (2023).

26.   Lin Y, Shi Q, Yang G, Shi F, Zhou Y, Wang T, Xu P, Li P, Liu Z, Sun H, Zhao Z, Ding K, Wang Z, Feng H, Yu B, Fang P, Wang J. A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB. Proc Natl Acad Sci USA, 120(7):e2213670120 (2023).

25.   Hou W, Wang M, Wang J, Cao X, Xu P, Yu B. Collective Synthesis and Cytotoxicities of Wentilactone Type Norditerpenoid Dilactones.  Asian Journal of Organic Chemistry. 12(1): e202200646. (2023).

24.   Qiao H, Xia M, Cheng Y, Zhou J, Zheng L, Li W, Wang J, Fang P. Tyrosine-targeted covalent inhibition of a tRNA synthetase aided by zinc ion.  Commun Biol. 6(1):107. (2023).

23.   Liu Z, Chen K, Dai J, Xu P, Sun W, Liu W, Zhao Z, Bennett SP, Li P, Ma T, Lin Y, Kawakami A, Yu J, Wang F, Wang C, Li M, Chase P, Hodder P, Spicer TP, Scampavia L, Cao C, Pan L, Dong J, Chen Y, Yu B, Guo M, Fang P, Fisher DE, Wang J. A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Research, 33(1):55-70 (2023).

22.   Cao X, Du X, Jiao H, An Q, Chen R, Fang P, Wang J, Yu B. Carbohydrate-based drugs launched during 2000-2021. Acta Pharmaceutica Sinica B, 12(10):3783-3821 (2022).

21.   Wu S, Zheng L, Hei Z, Zhou JB, Li G, Li P, Wang J, Ali H, Zhou XL, Wang J, Fang P. Human lysyl‑tRNA synthetase evolves a dynamic structure that can be stabilized by forming complex. Cellular and Molecular Life Sciences, 79, 128 (2022).

20.   Yang Q, Wang W, Lin Y, Lin Y, Tang Z, Wang J, Tao J, Tang W, Liu W. Characterization of a carboxyl methyltransferase in Fusarium graminearum provides insights into the biosynthesis of fusarin A. Organic & Biomolecular Chemistry, 19, 6638-6643 (2021).

19.   Yang G, Li P, Liu Z, Wu S, Zhuang C, Qiao H, Zheng L, Fang P, Lei C, Wang J. Structural basis for the dimerization mechanism of human transcription factor E3. Biochemical and Biophysical Research Communications, 569, 41-46 (2021).

18. Ye F, Zhao J, Xu P, Liu X, Yu J, Shangguan W, Liu J, Luo X, Li C, Ying T, Wang J, Yu B, Wang P. Synthetic Homogeneous Glycoforms of the SARS-CoV-2 Spike Receptor-Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies. Angewandte Chemie International Edition. 60, 12904-12910 (2021).

17.   Wu S, Hei Z, Zheng L, Zhou J, Liu Z, Wang J, Fang P. Structural analyses of a human lysyl-tRNA synthetase mutant associated with autosomal recessive nonsyndromic hearing impairment. Biochemical and Biophysical Research Communications, 554, 83-88 (2021).

16.   Hei Z, Wu S, Zheng L, Zhou J, Liu Z, Wang J, Fang P. Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2. Biochemical and Biophysical Research Communications, 549, 165-170 (2021).

15.   Zhou J, Huang Z, Zheng L, Hei Z, Wang Z, Yu B, Jiang L, Wang J, Fang P. Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via an Anaplastic Lymphoma Kinase Inhibitor. Nucleic Acids Research, 48, 11566-11576 (2020).

14.   Zhou J, Zheng L, Hei Z, Li W, Wang J, Yu B, Fang P. Atomic resolution analyses of isocoumarin derivatives for inhibition of lysyl-tRNA synthetase. ACS chemical biology, 15, 1016-1025 (2020).

13.   Yu J, Liu Z, Liang Y, Luo F, Zhang J, Tian C, Motzik A, Zheng M, Kang J, Zhong G, Liu C, Fang P, Guo M, Razin E, Wang J. Second Messenger Ap4A Polymerizes Target Protein HINT1 to Transduce Signals in Fc¦ÅRI-activated Mast Cells. Nature communications 10, 4664 (2019).

12.   Hei Z, Wu S, Liu Z, Wang J, Fang P. Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex. The Journal of biological chemistry 294, 4775-4783 (2019). 

11.   Wang J, Fang P, Chase P, Tshori S, Razin E, Spicer TP, et al. Development of an HTS-Compatible Assay for Discovery of Melanoma-Related Microphthalmia Transcription Factor Disruptors Using AlphaScreen Technology. SLAS discovery : advancing life sciences R & D 22, 58-66 (2017). 

10.   Motzik A, Amir E, Erlich T, Wang J, Kim BG, Han JM, et al. Post-translational modification of HINT1 mediates activation of MITF transcriptional activity in human melanoma cells. Oncogene 36, 4732-4738 (2017). 

9.     Fang P, Han H, Wang J, Chen K, Chen X, Guo M. Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor. Chemistry & biology 22, 734-744 (2015). 

8.     Kim DG, Lee JY, Kwon NH, Fang P, Zhang Q, Wang J, et al. Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction. Nature Chemical Biology 10, 29-34 (2014). 

7.     Ofir-Birin Y, Fang P, Bennett SP, Zhang HM, Wang J, Rachmin I, et al. Structural switch of lysyl-tRNA synthetase between translation and transcription. Mol Cell 49, 30-42 (2013). 

6.     Wang J, Fang P, Schimmel P, Guo M. Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor. The journal of physical chemistry B 116, 6798-6805 (2012). 

5.     Xing L, Zhu Y, Fang P, Wang J, Zeng F, Li X, et al. Crystallization and preliminary crystallographic studies of UbiG, an O-methyltransferase from Escherichia coli. Acta crystallographica Section F, Structural biology and crystallization communications 67, 727-729 (2011). 

4.     Wang J, Gossing M, Fang P, Zimmermann J, Li X, von Mollard GF, et al. Epsin N-terminal homology domains bind on opposite sides of two SNAREs. Proc Natl Acad Sci U S A 108, 12277-12282 (2011). 

3.     Fang P, Li X, Wang J, Xing L, Gao Y, Niu L, et al. Crystal structure of the protein L-isoaspartyl methyltransferase from Escherichia coli. Cell biochemistry and biophysics 58, 163-167 (2010). 

2.     Fang P, Li X, Wang J, Niu L, Teng M. Structural basis for the specificity of the GAE domain of yGGA2 for its accessory proteins Ent3 and Ent5. Biochemistry 49, 7949-7955 (2010). 

1.     Fang P, Wang J, Li X, Guo M, Xing L, Cao X, et al. Crystallization and preliminary X-ray analysis of Escherichia coli RNase G. Acta crystallographica Section F, Structural biology and crystallization communications 65, 586-588 (2009).

 

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